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  1. Infectious diseases have changed the course of whole civilizations. There is archaeological evidence suggesting that plagues may have wiped out or caused huge changes in several prehistoric civilizations.(1) The Antonine Plague (2) of 165–180 AD was a major factor in weakening the Roman Empire to the point that it could be defeated. Most people think it was smallpox but we can’t be sure. Black Death(3) was the most devastating pandemic in human history killing 75–200 million people in Eurasia. It came in waves starting in the 14th century with periodic recurrences until the 16th century. European diseases that arrived with explorers and colonists like smallpox and measles decimated Native American populations. European diseases so depopulated Native Americans that they could only be a minor nuisance to European interlopers. Smallpox allowed the Aztec and Incan civilizations with thousands of warriors to be sacked by a few hundred Spanish Conquistadores.(4) The 1918 Flu Pandemic(5) killed 50–100 million people worldwide and pushed the war weary and flu ravaged combatants of World War I to the peace table in Versailles. These were just the big outbreaks that changed the courses of whole civilizations. Other diseases were a constant menace like cholera, typhoid, typhus, measles, consumption (tuberculosis and pneumonia) and other treatable diseases today that were fatal without antibiotics and mass immunizations. Humanity survived for thousands of years without vaccination but, infectious diseases have definitely left their mark. It is a great fear of doctors and government officals that a virus might mutate or be created by a mad man that no one has any immunity to. With world populations so high, dense and mobile, there would be nothing to stop it from killing billions. Worse still- over use of antibiotics and disinfectants is creating drug resistant strains of old diseases that are now emerging threats. (6) We only THINK that we are done with infectious diseases. They are not done with us. We can only vaccinate against the worst of them and use good public health practices to contain outbreaks when they do occur. Least we forget: the HIV/AIDS pandemic emerged in the early eighties and has killed millions world wide. Modern medicine and our modern world are not immune to emerging infectious diseases or new strains of the old diseases that have dogged humanity since prehistoric times. _________________________________________________________ Footnotes: 1- DNA Evidence that Plague Started Much Earlier Than Thought https://www.nytimes.com/2015/10/23/science/in-ancient-dna-evidence-of-plague-much-earlier-than-previously-known.html 2- Antoine Plague https://en.wikipedia.org/wiki/Antonine_Plague 3- Black Death https://en.wikipedia.org/wiki/Black_Death 4- Native American Diseases & Epidemics https://en.wikipedia.org/wiki/Native_American_disease_and_epidemics 5- 1918 Flu Pandemic https://en.wikipedia.org/wiki/1918_flu_pandemic 6- Dangerous Drug Resistant Infections on the Rise Among Children https://www.washingtonpost.com/news/to-your-health/wp/2017/02/25/dangerous-antibiotic-resistant-infections-on-the-rise-for-children-in-the-u-s-study-finds/?utm_term=.15672308e593 Further Reading: Garrett, Laura The Coming Plague Quammen, David Spillover: Animal Infections and the Next Human Pandemic
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