On the topic of spelling errors, I would say that today there's really no excuse for making egregious and amateurish spelling errors, no matter how Alpha the manuscript. If you want someone to read and review your work, then you owe it to your readers to check spelling. There are just too many embedded tools and even 3rd party apps (and context-sensitive apps) for catching errors, even for authors with a sophisticated vocabulary in their creative toolbox. Nothing will stop an agent, publisher, or contest judge quicker than a careless transposition ('wierd') or misplaced homonym ('your the best'). And, from my point of view, spelling due diligence isn't just a fussy academic concern; as a reader, I want to forget about the mechanics of the author's writing and enter his or her world. A misspelling is a stone on the path, a banana peel, a crack in the pavement that makes me stumble and momentarily forget where I was. No author wants that.