No cross up Reader. I was asking about CDB, but mentioned that I had wicked joint pain as a side effect from the metformin, and had to refuse to take it in order to get relief. Am now researching CDB as an alternative to knee and back pain. They tell me they can do nothing for my knee till I am old enough to replace it, and the odd way I walk with the bad knee causes back pain. I keep telling them I would fix the knee now and if it needs to be redone in 15 or 20 years so what, thats better than waiting till I am over 65! Not walking so good at 79 sounds a lot better to me than now at 59.